Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis.
Identifieur interne : 000594 ( Main/Exploration ); précédent : 000593; suivant : 000595Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis.
Auteurs : Xavier Bossuyt [Belgique] ; Jan-Willem Cohen Tervaert [Pays-Bas] ; Yoshihiro Arimura [Japon] ; Daniel Blockmans [Belgique] ; Luis Felipe Flores-Suárez [Mexique] ; Loïc Guillevin [France] ; Bernhard Hellmich [Allemagne] ; David Jayne [Royaume-Uni] ; J Charles Jennette [États-Unis] ; Cees G M. Kallenberg [Pays-Bas] ; Sergey Moiseev [Russie] ; Pavel Novikov [Russie] ; Antonella Radice [Italie] ; Judith Anne Savige [Australie] ; Renato Alberto Sinico [Italie] ; Ulrich Specks [États-Unis] ; Pieter Van Paassen [Pays-Bas] ; Ming-Hui Zhao [République populaire de Chine] ; Niels Rasmussen [Danemark] ; Jan Damoiseaux [Pays-Bas] ; Elena Csernok [Allemagne]Source :
- Nature reviews. Rheumatology [ 1759-4804 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antibodies, Antineutrophil Cytoplasmic.
- diagnosis : Granulomatosis with Polyangiitis, Microscopic Polyangiitis.
- immunology : Granulomatosis with Polyangiitis, Microscopic Polyangiitis.
- Consensus, Humans.
Abstract
Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation.
DOI: 10.1038/nrrheum.2017.140
PubMed: 28905856
Affiliations:
- Allemagne, Australie, Belgique, Danemark, France, Italie, Japon, Mexique, Pays-Bas, Royaume-Uni, Russie, République populaire de Chine, États-Unis
- Angleterre, Angleterre de l'Est, District fédéral central, Lombardie, Province du Brabant flamand, Région de Kantō, Victoria (État), Île-de-France
- Cambridge, Louvain, Melbourne, Milan, Moscou, Paris, Tokyo
- Université Paris-Descartes, Université de Cambridge, Université de Melbourne
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wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck</wicri:regionArea><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion></affiliation></author><author><name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0SP, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0SP</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Jennette, J Charles" sort="Jennette, J Charles" uniqKey="Jennette J" first="J Charles" last="Jennette">J Charles Jennette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of North Carolina, 160 Medical Drive, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of North Carolina, 160 Medical Drive, Chapel Hill, North Carolina 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Kallenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, AA21, University Medical Centre Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, AA21, University Medical Centre Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Moiseev, Sergey" sort="Moiseev, Sergey" uniqKey="Moiseev S" first="Sergey" last="Moiseev">Sergey Moiseev</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Novikov, Pavel" sort="Novikov, Pavel" uniqKey="Novikov P" first="Pavel" last="Novikov">Pavel Novikov</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Radice, Antonella" sort="Radice, Antonella" uniqKey="Radice A" first="Antonella" last="Radice">Antonella Radice</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology and Virology Institute, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Via Pio II 3, 20153 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Microbiology and Virology Institute, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Via Pio II 3, 20153 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Savige, Judith Anne" sort="Savige, Judith Anne" uniqKey="Savige J" first="Judith Anne" last="Savige">Judith Anne Savige</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Melbourne Health, The University of Melbourne, Grattan Street, Parkville, Melbourne VIC 3050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Melbourne Health, The University of Melbourne, Grattan Street, Parkville, Melbourne VIC 3050</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sinico, Renato Alberto" sort="Sinico, Renato Alberto" uniqKey="Sinico R" first="Renato Alberto" last="Sinico">Renato Alberto Sinico</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Via Cadore, 48, 20900 Monza MB, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Via Cadore, 48, 20900 Monza MB</wicri:regionArea><wicri:noRegion>20900 Monza MB</wicri:noRegion></affiliation></author><author><name sortKey="Specks, Ulrich" sort="Specks, Ulrich" uniqKey="Specks U" first="Ulrich" last="Specks">Ulrich Specks</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary & Critical Medicine, Mayo Clinic, Rochester, 200 First Street, Rochester, Minnesota 55905, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary & Critical Medicine, Mayo Clinic, Rochester, 200 First Street, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Van Paassen, Pieter" sort="Van Paassen, Pieter" uniqKey="Van Paassen P" first="Pieter" last="Van Paassen">Pieter Van Paassen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Section Nephrology and Immunology, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Section Nephrology and Immunology, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht</wicri:regionArea><wicri:noRegion>6229 HX Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Ming Hui" sort="Zhao, Ming Hui" uniqKey="Zhao M" first="Ming-Hui" last="Zhao">Ming-Hui Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Renal Division, Peking University First Hospital; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China; Peking-Tsinghua Centre for Life Sciences; 8 Xishiku Street, Xichengqu, Beijing Shi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Renal Division, Peking University First Hospital; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China; Peking-Tsinghua Centre for Life Sciences; 8 Xishiku Street, Xichengqu, Beijing Shi</wicri:regionArea><wicri:noRegion>Beijing Shi</wicri:noRegion></affiliation></author><author><name sortKey="Rasmussen, Niels" sort="Rasmussen, Niels" uniqKey="Rasmussen N" first="Niels" last="Rasmussen">Niels Rasmussen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Autoimmunology and Biomarkers, Statens Seruminstitut, Artillerivej 5, 2300 Copenhagen S, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Autoimmunology and Biomarkers, Statens Seruminstitut, Artillerivej 5, 2300 Copenhagen S</wicri:regionArea><wicri:noRegion>2300 Copenhagen S</wicri:noRegion></affiliation></author><author><name sortKey="Damoiseaux, Jan" sort="Damoiseaux, Jan" uniqKey="Damoiseaux J" first="Jan" last="Damoiseaux">Jan Damoiseaux</name><affiliation wicri:level="1"><nlm:affiliation>Central Diagnostic Laboratory, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Central Diagnostic Laboratory, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht</wicri:regionArea><wicri:noRegion>6229 HX Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Csernok, Elena" sort="Csernok, Elena" uniqKey="Csernok E" first="Elena" last="Csernok">Elena Csernok</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck</wicri:regionArea><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter 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type="wicri:Area/Main/Exploration">000594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis.</title><author><name sortKey="Bossuyt, Xavier" sort="Bossuyt, Xavier" uniqKey="Bossuyt X" first="Xavier" last="Bossuyt">Xavier Bossuyt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, University of Leuven and Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Herestraat 49, 3000 Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Microbiology and Immunology, University of Leuven and Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Herestraat 49, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Cohen Tervaert, Jan Willem" sort="Cohen Tervaert, Jan Willem" uniqKey="Cohen Tervaert J" first="Jan-Willem" last="Cohen Tervaert">Jan-Willem Cohen Tervaert</name><affiliation wicri:level="1"><nlm:affiliation>Maastricht University, Universiteitssingel 40, 6229 Maastricht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Maastricht University, Universiteitssingel 40, 6229 Maastricht</wicri:regionArea><wicri:noRegion>6229 Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Arimura, Yoshihiro" sort="Arimura, Yoshihiro" uniqKey="Arimura Y" first="Yoshihiro" last="Arimura">Yoshihiro Arimura</name><affiliation wicri:level="1"><nlm:affiliation>Kichijoji Asahi Hospital, 11-30-12 Kichijoji Honcho, Musashino, Tokyo 181-8611, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Kichijoji Asahi Hospital, 11-30-12 Kichijoji Honcho, Musashino, Tokyo 181-8611</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Blockmans, Daniel" sort="Blockmans, Daniel" uniqKey="Blockmans D" first="Daniel" last="Blockmans">Daniel Blockmans</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Department of General Internal Medicine, Research Department of Microbiology and Immunology and Laboratory of Clinical Infectious and Inflammatory Disorders, University Hospitals Leuven, Leuven, Herestraat 49, 3000 Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinical Department of General Internal Medicine, Research Department of Microbiology and Immunology and Laboratory of Clinical Infectious and Inflammatory Disorders, University Hospitals Leuven, Leuven, Herestraat 49, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Flores Suarez, Luis Felipe" sort="Flores Suarez, Luis Felipe" uniqKey="Flores Suarez L" first="Luis Felipe" last="Flores-Suárez">Luis Felipe Flores-Suárez</name><affiliation wicri:level="1"><nlm:affiliation>Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Colonia Sección XVI, CP 14080, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Colonia Sección XVI, CP 14080, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Guillevin, Loic" sort="Guillevin, Loic" uniqKey="Guillevin L" first="Loïc" last="Guillevin">Loïc Guillevin</name><affiliation wicri:level="4"><nlm:affiliation>National Referral Centre for Necrotizing Vasculitides and Systemic Sclerosis, Université Paris Descartes, Hôpital Cochin, L'Assistance Publique-Hôpitaux de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Referral Centre for Necrotizing Vasculitides and Systemic Sclerosis, Université Paris Descartes, Hôpital Cochin, L'Assistance Publique-Hôpitaux de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014</wicri:regionArea><wicri:noRegion>75014</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Hellmich, Bernhard" sort="Hellmich, Bernhard" uniqKey="Hellmich B" first="Bernhard" last="Hellmich">Bernhard Hellmich</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck</wicri:regionArea><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion></affiliation></author><author><name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0SP, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0SP</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Jennette, J Charles" sort="Jennette, J Charles" uniqKey="Jennette J" first="J Charles" last="Jennette">J Charles Jennette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of North Carolina, 160 Medical Drive, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of North Carolina, 160 Medical Drive, Chapel Hill, North Carolina 27599</wicri:regionArea><wicri:noRegion>North Carolina 27599</wicri:noRegion></affiliation></author><author><name sortKey="Kallenberg, Cees G M" sort="Kallenberg, Cees G M" uniqKey="Kallenberg C" first="Cees G M" last="Kallenberg">Cees G M. Kallenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, AA21, University Medical Centre Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, AA21, University Medical Centre Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Moiseev, Sergey" sort="Moiseev, Sergey" uniqKey="Moiseev S" first="Sergey" last="Moiseev">Sergey Moiseev</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Novikov, Pavel" sort="Novikov, Pavel" uniqKey="Novikov P" first="Pavel" last="Novikov">Pavel Novikov</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Clinic of Nephrology, Internal and Occupational Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow 119435</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Radice, Antonella" sort="Radice, Antonella" uniqKey="Radice A" first="Antonella" last="Radice">Antonella Radice</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology and Virology Institute, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Via Pio II 3, 20153 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Microbiology and Virology Institute, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Via Pio II 3, 20153 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Savige, Judith Anne" sort="Savige, Judith Anne" uniqKey="Savige J" first="Judith Anne" last="Savige">Judith Anne Savige</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Melbourne Health, The University of Melbourne, Grattan Street, Parkville, Melbourne VIC 3050, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Melbourne Health, The University of Melbourne, Grattan Street, Parkville, Melbourne VIC 3050</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sinico, Renato Alberto" sort="Sinico, Renato Alberto" uniqKey="Sinico R" first="Renato Alberto" last="Sinico">Renato Alberto Sinico</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Via Cadore, 48, 20900 Monza MB, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Via Cadore, 48, 20900 Monza MB</wicri:regionArea><wicri:noRegion>20900 Monza MB</wicri:noRegion></affiliation></author><author><name sortKey="Specks, Ulrich" sort="Specks, Ulrich" uniqKey="Specks U" first="Ulrich" last="Specks">Ulrich Specks</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary & Critical Medicine, Mayo Clinic, Rochester, 200 First Street, Rochester, Minnesota 55905, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary & Critical Medicine, Mayo Clinic, Rochester, 200 First Street, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Van Paassen, Pieter" sort="Van Paassen, Pieter" uniqKey="Van Paassen P" first="Pieter" last="Van Paassen">Pieter Van Paassen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Section Nephrology and Immunology, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Section Nephrology and Immunology, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht</wicri:regionArea><wicri:noRegion>6229 HX Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Ming Hui" sort="Zhao, Ming Hui" uniqKey="Zhao M" first="Ming-Hui" last="Zhao">Ming-Hui Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Renal Division, Peking University First Hospital; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China; Peking-Tsinghua Centre for Life Sciences; 8 Xishiku Street, Xichengqu, Beijing Shi, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Renal Division, Peking University First Hospital; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China; Peking-Tsinghua Centre for Life Sciences; 8 Xishiku Street, Xichengqu, Beijing Shi</wicri:regionArea><wicri:noRegion>Beijing Shi</wicri:noRegion></affiliation></author><author><name sortKey="Rasmussen, Niels" sort="Rasmussen, Niels" uniqKey="Rasmussen N" first="Niels" last="Rasmussen">Niels Rasmussen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Autoimmunology and Biomarkers, Statens Seruminstitut, Artillerivej 5, 2300 Copenhagen S, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Autoimmunology and Biomarkers, Statens Seruminstitut, Artillerivej 5, 2300 Copenhagen S</wicri:regionArea><wicri:noRegion>2300 Copenhagen S</wicri:noRegion></affiliation></author><author><name sortKey="Damoiseaux, Jan" sort="Damoiseaux, Jan" uniqKey="Damoiseaux J" first="Jan" last="Damoiseaux">Jan Damoiseaux</name><affiliation wicri:level="1"><nlm:affiliation>Central Diagnostic Laboratory, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Central Diagnostic Laboratory, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht</wicri:regionArea><wicri:noRegion>6229 HX Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Csernok, Elena" sort="Csernok, Elena" uniqKey="Csernok E" first="Elena" last="Csernok">Elena Csernok</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Centre Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Eugenstrasse 3, 73230 Kirchheim unter Teck</wicri:regionArea><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion><wicri:noRegion>73230 Kirchheim unter Teck</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. Rheumatology</title><idno type="eISSN">1759-4804</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Antineutrophil Cytoplasmic (immunology)</term><term>Consensus</term><term>Granulomatosis with Polyangiitis (diagnosis)</term><term>Granulomatosis with Polyangiitis (immunology)</term><term>Humans</term><term>Microscopic Polyangiitis (diagnosis)</term><term>Microscopic Polyangiitis (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps anticytoplasme des polynucléaires neutrophiles (immunologie)</term><term>Consensus</term><term>Granulomatose avec polyangéite (diagnostic)</term><term>Granulomatose avec polyangéite (immunologie)</term><term>Humains</term><term>Polyangéite microscopique (diagnostic)</term><term>Polyangéite microscopique (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Antineutrophil Cytoplasmic</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Granulomatosis with Polyangiitis</term><term>Microscopic Polyangiitis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Granulomatose avec polyangéite</term><term>Polyangéite microscopique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps anticytoplasme des polynucléaires neutrophiles</term><term>Granulomatose avec polyangéite</term><term>Polyangéite microscopique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Granulomatosis with Polyangiitis</term><term>Microscopic Polyangiitis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Consensus</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Consensus</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Japon</li><li>Mexique</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>District fédéral central</li><li>Lombardie</li><li>Province du Brabant flamand</li><li>Région de Kantō</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Louvain</li><li>Melbourne</li><li>Milan</li><li>Moscou</li><li>Paris</li><li>Tokyo</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Cambridge</li><li>Université de Melbourne</li></orgName></list><tree><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Bossuyt, Xavier" sort="Bossuyt, Xavier" uniqKey="Bossuyt X" first="Xavier" last="Bossuyt">Xavier Bossuyt</name></region><name sortKey="Blockmans, Daniel" sort="Blockmans, Daniel" uniqKey="Blockmans D" first="Daniel" last="Blockmans">Daniel Blockmans</name></country><country name="Pays-Bas"><noRegion><name sortKey="Cohen Tervaert, Jan Willem" sort="Cohen Tervaert, Jan Willem" uniqKey="Cohen Tervaert J" first="Jan-Willem" last="Cohen Tervaert">Jan-Willem Cohen Tervaert</name></noRegion><name sortKey="Damoiseaux, Jan" sort="Damoiseaux, Jan" uniqKey="Damoiseaux J" first="Jan" last="Damoiseaux">Jan Damoiseaux</name><name sortKey="Kallenberg, Cees G M" sort="Kallenberg, Cees G M" uniqKey="Kallenberg C" first="Cees G M" last="Kallenberg">Cees G M. Kallenberg</name><name sortKey="Van Paassen, Pieter" sort="Van Paassen, Pieter" uniqKey="Van Paassen P" first="Pieter" last="Van Paassen">Pieter Van Paassen</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Arimura, Yoshihiro" sort="Arimura, Yoshihiro" uniqKey="Arimura Y" first="Yoshihiro" last="Arimura">Yoshihiro Arimura</name></region></country><country name="Mexique"><noRegion><name sortKey="Flores Suarez, Luis Felipe" sort="Flores Suarez, Luis Felipe" uniqKey="Flores Suarez L" first="Luis Felipe" last="Flores-Suárez">Luis Felipe Flores-Suárez</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Guillevin, Loic" sort="Guillevin, Loic" uniqKey="Guillevin L" first="Loïc" last="Guillevin">Loïc Guillevin</name></region></country><country name="Allemagne"><noRegion><name sortKey="Hellmich, Bernhard" sort="Hellmich, Bernhard" uniqKey="Hellmich B" first="Bernhard" last="Hellmich">Bernhard Hellmich</name></noRegion><name sortKey="Csernok, Elena" sort="Csernok, Elena" uniqKey="Csernok E" first="Elena" last="Csernok">Elena Csernok</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name></region></country><country name="États-Unis"><noRegion><name sortKey="Jennette, J Charles" sort="Jennette, J Charles" uniqKey="Jennette J" first="J Charles" last="Jennette">J Charles Jennette</name></noRegion><name sortKey="Specks, Ulrich" sort="Specks, Ulrich" uniqKey="Specks U" first="Ulrich" last="Specks">Ulrich Specks</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Moiseev, Sergey" sort="Moiseev, Sergey" uniqKey="Moiseev S" first="Sergey" last="Moiseev">Sergey Moiseev</name></region><name sortKey="Novikov, Pavel" sort="Novikov, Pavel" uniqKey="Novikov P" first="Pavel" last="Novikov">Pavel Novikov</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Radice, Antonella" sort="Radice, Antonella" uniqKey="Radice A" first="Antonella" last="Radice">Antonella Radice</name></region><name sortKey="Sinico, Renato Alberto" sort="Sinico, Renato Alberto" uniqKey="Sinico R" first="Renato Alberto" last="Sinico">Renato Alberto Sinico</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Savige, Judith Anne" sort="Savige, Judith Anne" uniqKey="Savige J" first="Judith Anne" last="Savige">Judith Anne Savige</name></region></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Ming Hui" sort="Zhao, Ming Hui" uniqKey="Zhao M" first="Ming-Hui" last="Zhao">Ming-Hui Zhao</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Rasmussen, Niels" sort="Rasmussen, Niels" uniqKey="Rasmussen N" first="Niels" last="Rasmussen">Niels Rasmussen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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